您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > SX-682
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
SX-682
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SX-682图片
CAS NO:1648843-04-2
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
SX-682 是口服有效的 CXCR1 和 CXCR2 变构抑制剂。SX-682 可以阻断肿瘤髓系抑制细胞 (MDSCs) 募集并增强 T 细胞活化和抗肿瘤免疫。
Cas No.1648843-04-2
Canonical SMILESO=C(NC1=CC=C(F)C=C1)C(C=N2)=CN=C2SCC3=CC(OC(F)(F)F)=CC=C3B(O)O
分子式C19H14BF4N3O4S
分子量467.2
溶解度DMSO: 250 mg/mL (535.10 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SX-682 is an orally bioavailable, potent allosteric inhibitor of CXCR1 and CXCR2. SX-682 can block tumor myeloid-derived suppressor cells (MDSCs) recruitment and enhance T cell activation and antitumor immunity[1].

[1]. Sun L, et al. Inhibiting myeloid-derived suppressor cell trafficking enhances T cell immunotherapy. JCI Insight. 2019 Apr 4;4(7).