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TCPOBOP
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
TCPOBOP图片
CAS NO:76150-91-9
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
TCPOBOP 是一种组成型雄甾烷受体 (CAR) 激动剂，可诱导强大的肝细胞增殖和肝肿大，而不会造成任何肝损伤或组织损失。 TCPOBOP 通过改变 Bcl-2 蛋白减轻 Fas 诱导的小鼠肝损伤。
Cas No.76150-91-9
化学名1,4-bis((3,5-dichloropyridin-2-yl)oxy)benzene
Canonical SMILESClC1=CC(Cl)=CN=C1OC(C=C2)=CC=C2OC(C(Cl)=C3)=NC=C3Cl
分子式C16H8Cl4N2O2
分子量402.06
溶解度DMF: 3 mg/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss[1]. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins[2].

TCPOBOP (oral; 3 mg/kg; 1-5 days) remarkable increases Liver weight to body weight in LW/BW ratio at 48 hours[1].

References:
[1]. Bhushan B, et al. TCPOBOP-Induced Hepatomegaly and Hepatocyte Proliferation are Attenuated by Combined Disruption of MET and EGFR Signaling. Hepatology. 2019 Apr;69(4):1702-1718.
[2]. Baskin-Bey ES, et al. Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Hepatology. 2006 Jul;44(1):252-62.