CAS NO: | 138968-86-2 |
包装: | 1mg |
市场价: | 7031元 |
Cas No. | 138968-86-2 |
Canonical SMILES | O=C(C1=C(CCCCC)C=C(CCC2=C(C3=C(C=C24)C(C)(C)C5=C(C(O)=CC(O)=C5)C3=O)O)C4=C1O)O |
分子式 | C30H30O7 |
分子量 | 502.6 |
储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Benastatin B is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.1,2,3It inhibits glutathione S-transferase (GST; Ki= 3.7 µM for the rat liver enzyme).2Benastatin B also inhibits the transglycosylase activity ofA. baumannii,C. difficile,E. coli, andS. aureusrecombinant penicillin-binding proteins (PBPs; IC50s = 16, 53.3, 30.7, and 31.6 µM, respectively).3It is active against several bacteria, including methicillin-resistantS. aureus(MRSA; MIC = 3.12 µg/ml).2 1.Xu, Z., Schenk, A., and Hertweck, C.Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of altered fatty acid-polyketide hybridsJ. Am. Chem. Soc.129(18)6022-6030(2007) 2.Aoyagi, T., Aoyama, T., Kojima, F., et al.Benastatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. I. Taxonomy, production, isolation, physico-chemical properties and biological activitiesJ. Antibiot. (Tokyo)45(9)1385-1390(1992) 3.Wu, W.-S., Cheng, W.-C., Cheng, T.-J.R., et al.Affinity-based screen for inhibitors of bacterial transglycosylaseAm. Chem. Soc.140(8)2752-2755(2018) |