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Galanin(Human)(Acetate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
包装:1mg
市场价:3704元

产品介绍
A neuropeptide and GAL receptor agonist
Canonical SMILESO=C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@]([C@H](O)C)([H])C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@H](C(NCC(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@H](C(N[C@H](C(NCC(N4CCC[C@H]4C(N[C@@H](CC5=CNC=N5)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N[C@@H](CC(N)=O)C(N[C@@H](CC6=CNC=N6)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN[H])C(N[C@@H](CC(N)=O)C(NCC(N[C@H](C(N[C@]([C@H](O)C)([H])C(N[C@@H](CO)C(O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)CC7=CC=CC=C7)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)C)=O)=O)=O)CC(C)C)=O)=O)CN[H].CC(O)=O
分子式C139H210N42O43•XC2H4O2
分子量3157.4
溶解度Water: 1 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Human galanin is a 30-amino acid neuropeptide and galanin (GAL) receptor agonist.1,2,3,4It inhibits forskolin-induced cAMP production in HEK293E cells expressing recombinant human GAL1receptors (EC50= 0.031 nM) and stimulates inositol phosphate accumulation in CHO cells expressing recombinant human GAL2receptors (EC50= 12.3 nM).1,2Human galanin induces contractions in isolated rat longitudinal fundus strips with an EC50value of 13.8 nM.3Intrathecal administration of human galanin (3, 10, and 30 nmol/animal) reduces paw licking and flinching in the second, but not first, phase of the formalin test in rats.4

1.Fitzgerald, L.W., Patterson, J.P., Conklin, D.S., et al.Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: Agonist character of chimeric galanin peptidesJ. Pharmacol. Exp. Ther.287(2)448-456(1998) 2.Borowsky, B., Walker, M.W., Huang, L.Y., et al.Cloning and characterization of the human galanin GALR2 receptorPeptides19(10)1771-1781(1998) 3.Schmidt, W.E., Kratzin, H., Eckart, K., et al.Isolation and primary structure of pituitary human galanin, a 30-residue nonamidated neuropeptideProc. Natl. Acad. Sci. USA88(24)11435-11439(1991) 4.Hua, X.-Y., Hayes, C.S., Hofer, A., et al.Galanin acts at GalR1 receptors in spinal antinociception: Synergy with morphine and AP-5J. Pharmacol. Exp. Ther.308(2)574-582(2004)