An internal standard for the quantification of prostaglandin D
2| Cas No. | 211105-29-2 |
| 别名 | PGD2-d4 |
| Canonical SMILES | O[C@@H](C1)[C@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)C1=O |
| 分子式 | C20H28D4O5 |
| 分子量 | 356.5 |
| 溶解度 | DMF: >100 mg/ml (from PGD2),DMSO: >50 mg/ml (from PGD2),Ethanol: >75 mg/ml (from PGD2),PBS pH 7.2: >5 mg/ml (from PGD2) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Prostaglandin D2-d4(PGD2-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGD2by GC-or LC-mass spectrometry. PGD2is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Mastocytosis patients produce excessive amounts of PGD2, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD2is also produced in the brainviaan alternative pathway involving a soluble, secreted PGD-synthase also known as β-trace.2,3 In the brain, PGD2produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2inhibits human ovarian tumor cell proliferation with an IC50of 6.8 µM. N/A |
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