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Nabumetone-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nabumetone-d3图片
CAS NO:1216770-08-9
包装:1mg
市场价:3009元

产品介绍
An internal standard for the quantification of nabumetone
Cas No.1216770-08-9
别名萘丁美酮-D3,BRL14777-d3
Canonical SMILESCC(CCC1=CC2=CC=C(OC([2H])([2H])[2H])C=C2C=C1)=O
分子式C15H13D3O2
分子量231.3
溶解度Chloroform: slightly soluble,Ethyl Acetate: slightly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Nabumetone-d3is intended for use as an internal standard for the quantification of nabumetone by GC- or LC-MS. Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) and a prodrug form of 6-methoxy naphthalene acetic acid .1Nabumetone (5-45 mg/kg) reduces carrageenan-induced edema in rats, as well as UV-induced erythema in guinea pigs (ED50= 11 mg/kg).2It reduces phenyl-p-quinone-induced writhing in mice (ED50= 152 mg/kg). Nabumetone (50, 100, and 200 mg/kg) reduces endotoxin-induced pyresis in rabbits.

1.Cryer, B., and Feldman, M.Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugsAm. J. Med.104(5)413-421(1998) 2.Boyle, E.A., Freeman, P.C., Mangan, F.R., et al.Nabumetone (BRL 14777, 4-[6-methoxy-2-naphthyl]-butan-2-one): a new anti-inflammatory agentJ. Pharm. Pharmacol.34(9)562-569(1982)