CAS NO: | 122965-43-9 |
包装 | 价格(元) |
25 g | 电议 |
50 g | 电议 |
100 g | 电议 |
250 g | 电议 |
Cas No. | 122965-43-9 |
别名 | 亚甲基蓝水合物,Basic Blue 9 hydrate; CI-52015 hydrate; Methylthioninium chloride hydrate |
Canonical SMILES | CN(C)C1=CC2=[S+]C3=C(C=CC(N(C)C)=C3)N=C2C=C1.[Cl-].O |
分子式 | C16H18N3S.Cl [XH2O] |
分子量 | 319.9 |
溶解度 | DMF: 2 mg/ml,DMSO: 2 mg/ml,Ethanol: 3.3 mg/ml,PBS (pH 7.2): 0.14 mg/ml |
储存条件 | Store at RT |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Methylene blue is a cationic thiazine dye that has diverse biological activities.1,2,3It inhibits the catalytic function of inducible and constitutive nitric oxide synthasesviaoxidation of enzyme-bound ferrous iron.1Methylene blue also inhibits monoamine oxidase (MAO) and increases the activity of mitochondrial cytochrome C oxidase (complex IV).2,3In vivo, methylene blue stabilizes systemic circulation without increasing peripheral resistance, decreases lipid peroxidation, and reduces anoxic tissue injury in brain and heart in a porcine model of global ischemia and reperfusion injury.1It inhibits MAO activity in brain and reduces the age-related decline in grip strength and spatial memory in old mice when administered in drinking water at a concentration of 250 μM.2Methylene blue (15, 30, and 60 mg/kg) also reduces immobility time in the forced swim test in mice, indicating antidepressant-like activity.3Methylene blue is commonly used to stain cells and tissues in research.4 1.Wiklund, L., Basu, S., Miclescu, A., et al.Neuro- and cardioprotective effects of blockade of nitric oxide action by administration of methylene blueAnn. N.Y. Acad. Sci.1122(1)231-244(2007) 2.Gharib, A., and Atamna, H.Methylene blue induces mitochondrial complex IV and improves cognitive function and grip strength in old miceNeurodegeneration: Theory, disorders and treatments63-85(2011) 3.Harvey, B.H., Duvenhage, I., Viljoen, F., et al.Role of monoamine oxidase, nitric oxide synthase and regional brain monoamines in the antidepressant-like effects of methylene blue and selected structural analoguesBiochem. Pharmacol.80(10)1580-1591(2010) 4.Hu, X., Laguerre, V., Packert, D., et al.A simple and efficient method for preparing cell slides and staining without using cytocentrifuge and cytoclipsInt. J. Cell Biol.2015:813216813216(2015) |