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Methylene Blue(hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Methylene Blue(hydrate)图片
CAS NO:122965-43-9
包装与价格:
包装价格(元)
25 g电议
50 g电议
100 g电议
250 g电议

产品介绍
亚甲蓝 (Basic Blue 9) 水合物是一种鸟苷酸环化酶 (sGC)、单胺氧化酶 A (MAO-A) 和一氧化氮合酶 (NOS) 抑制剂。
Cas No.122965-43-9
别名亚甲基蓝水合物,Basic Blue 9 hydrate; CI-52015 hydrate; Methylthioninium chloride hydrate
Canonical SMILESCN(C)C1=CC2=[S+]C3=C(C=CC(N(C)C)=C3)N=C2C=C1.[Cl-].O
分子式C16H18N3S.Cl [XH2O]
分子量319.9
溶解度DMF: 2 mg/ml,DMSO: 2 mg/ml,Ethanol: 3.3 mg/ml,PBS (pH 7.2): 0.14 mg/ml
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Methylene blue is a cationic thiazine dye that has diverse biological activities.1,2,3It inhibits the catalytic function of inducible and constitutive nitric oxide synthasesviaoxidation of enzyme-bound ferrous iron.1Methylene blue also inhibits monoamine oxidase (MAO) and increases the activity of mitochondrial cytochrome C oxidase (complex IV).2,3In vivo, methylene blue stabilizes systemic circulation without increasing peripheral resistance, decreases lipid peroxidation, and reduces anoxic tissue injury in brain and heart in a porcine model of global ischemia and reperfusion injury.1It inhibits MAO activity in brain and reduces the age-related decline in grip strength and spatial memory in old mice when administered in drinking water at a concentration of 250 μM.2Methylene blue (15, 30, and 60 mg/kg) also reduces immobility time in the forced swim test in mice, indicating antidepressant-like activity.3Methylene blue is commonly used to stain cells and tissues in research.4

1.Wiklund, L., Basu, S., Miclescu, A., et al.Neuro- and cardioprotective effects of blockade of nitric oxide action by administration of methylene blueAnn. N.Y. Acad. Sci.1122(1)231-244(2007) 2.Gharib, A., and Atamna, H.Methylene blue induces mitochondrial complex IV and improves cognitive function and grip strength in old miceNeurodegeneration: Theory, disorders and treatments63-85(2011) 3.Harvey, B.H., Duvenhage, I., Viljoen, F., et al.Role of monoamine oxidase, nitric oxide synthase and regional brain monoamines in the antidepressant-like effects of methylene blue and selected structural analoguesBiochem. Pharmacol.80(10)1580-1591(2010) 4.Hu, X., Laguerre, V., Packert, D., et al.A simple and efficient method for preparing cell slides and staining without using cytocentrifuge and cytoclipsInt. J. Cell Biol.2015:813216813216(2015)