| CAS NO: | 1219798-80-7 |
| 包装 | 价格(元) |
| 500 μg | 电议 |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 1219798-80-7 |
| 别名 | 盐酸美哌隆-D4/盐酸甲哌酮-D4 |
| Canonical SMILES | CC(CC1([2H])[2H])CC([2H])([2H])N1CCCC(C2=CC=C(F)C=C2)=O.Cl |
| 分子式 | C16H18D4FNO.HCl |
| 分子量 | 303.8 |
| 溶解度 | DMF: soluble,DMSO: soluble,Ethanol: soluble,PBS (pH 7.2): soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Melperone-d4is intended for use as an internal standard for the quantification of melperone by GC- or LC-MS. Melperone is an atypical antipsychotic.1It binds to α1- and α2-adrenergic and dopamine D2receptors (Kds = 180, 150, and 180 nM, respectively), as well as the serotonin (5-HT) receptor subtype 5-HT2A(Kd= 102 nM). It is selective for these receptors over histamine H1, muscarinic, 5-HT1A, 5-HT1D, and 5-HT2Creceptors (Kds = 580, >10,000, 2,200, 3,400, and 2,100 nM, respectively). Melperone (2 mg/kg per day) increases basal, but not amphetamine-induced, extracellular dopamine levels in the rat nucleus accumbens.2 1.Richelson, E., and Souder, T.Binding of antipsychotic drugs to human brain receptors: Focus on newer generation compoundsLife Sci.68(1)29-39(2000) 2.Ichikawa, J., and Meltzer, H.Y.The effect of chronic atypical antipsychotic drugs and haloperidol on amphetamine-induced dopamine release in vivoBrain Res.574(1-2)98-104(1992) |
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