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NSC 319726
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NSC 319726图片
CAS NO:71555-25-4
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)234.32
FormulaC11H14N4S
CAS No.71555-25-4
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 19 mg/mL (81.08 mM)
Water:<1 mg/mL (slightly soluble or insoluble)
Ethanol: <1 mg/mL
SynonymsNSC319726; NSC-319726; NSC 319726
实验参考方法
GeneralNSC319726 (5mg/kg, 7days) exhibits greater toxicity for p53(R172H/R172H) mice, with only 30% survival, as compared to 100% survival for p53+/+ and p53-/- mice. NSC319726 inhibits the growth of TOV112D-p53(R175H) xenografts, but not H460 (p53+/+) and MDAMB468-p53(R273W) xenografts.
Animal modelp53+/+, p53-/- and p53R172H knockin mice
FormulationDMSO
Dosages5-10 mg/kg/day, up to 7 days
Administrationi.p.
References[1] Yu X, et al. Cancer Cell, 2012, 21(5), 614-625.