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Aristolochic Acid A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Aristolochic Acid A图片
CAS NO:313-67-7
包装:20mg
市场价:1848元

产品介绍
Aristolochic Acid A (Aristolochic acid I; TR 1736) 是植物提取物马兜铃酸的主要成分,存在于马兜铃属和细辛属的各种草本植物中。 Aristolochic Acid A 显着降低激活蛋白 1 (AP-1) 和 NF-κB 的活性。 Aristolochic Acid A 降低人类细胞系中的 BLCAP 基因表达。
Cas No.313-67-7
别名马兜铃酸 A; Aristolochic acid I; TR 1736
化学名8-methoxy-6-nitronaphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid
Canonical SMILESCOC1=CC=CC2=C3C(=C(C=C21)[N+](=O)[O-])C(=CC4=C3OCO4)C(=O)O
分子式C17H11NO7
分子量341.27
溶解度≥ 17.05mg/mL in DMSO with ultrasonic and warming
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines[1].

Aristolochic acid A (150, 200 μM, 24 hours) inhibits the cell viabilities of kidney cells HEK293 and HK-2[1].Aristolochic acid A (100, 200 μM, 24 hours) causes a concentration-dependent decrease in bladder cancer-associated protein (BLCAP) mRNA levels in kidney cells (HEK 293 and HK-2) , and bladder cancer cell line (HT-1376)[1].Aristolochic acid A (100, 200 μM, 24 hours) weakens the BLCAP protein signals in a dose-dependent manner in both HEK293 and HT-1376 cells[1].

References:
[1]. Huang YT, et al. Aristolochic acid I interferes with the expression of BLCAP tumor suppressor gene in human cells. Toxicol Lett. 2018 Jul;291:129-137.