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astragalin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
astragalin图片
CAS NO:480-10-4
包装:20mg
市场价:1901元

产品介绍
黄芪(Astragaline)是一种具有抗炎、抗氧化、抗癌、抑菌活性的黄酮类化合物。
Cas No.480-10-4
别名紫云英苷; Astragaline; 3-Glucosylkaempferol; Kaempferol 3-β-D-glucopyranoside
化学名5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
Canonical SMILESC1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O
分子式C21H20O11
分子量448.38
溶解度≥ 44.8mg/mL in DMSO
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Astragalin is an inhibitor of eotaxin-1, PKCβ2 phosphorylation, activation of NF-κB/MAPK and PLCγ1 that correlated with oxidase in a dose dependent manner [1] [2].
Oxidative stress means disturbances in the normal redox state of cells can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell. And it is reported that oxidative stress can cause disruptions in normal mechanisms of cellular signaling, such as cancer development, Parkinson's disease, Alzheimer's disease, atherosclerosis, passive cutaneous reactions, inflammation, heart failure, myocardial infarction, Sickle Cell Disease, infection, and chronic fatigue syndrome [1, 3]. In human osteoaithritis chondrocyte cells, astragalin inhibited the activation of NF-κB and MAPK [2].
Astragalin is reported to have the ability of anti-oxidant effect. When tested with human basophilic cell line KU812, oral administration of astragalin inhibited the release of histamine and passive cutaneous reactions [4]. In airway epithelial BEAS-2B cells, astragalin treatment antagonized endotoxin-induced oxidative stress that is responsible to airway dysfunction and inflammation [1]. When tested with human red blood cells induced in the oxidative state, administration of astragalin suppressed the [3].
In mouse model with NC/Nga atopic dermatitis, astragalin treatment significantly suppressed the dermatitis development, scratching behavior and serum IgE elevation [4].
References:
[1].    Cho, I.H., et al., Astragalin inhibits airway eotaxin-1 induction and epithelial apoptosis through modulating oxidative stress-responsive MAPK signaling. BMC Pulm Med, 2014. 14: p. 122.
[2].    Ma, Z., et al., Astragalin inhibits IL-1beta-induced inflammatory mediators production in human osteoarthritis chondrocyte by inhibiting NF-kappaB and MAPK activation. Int Immunopharmacol, 2015. 25(1): p. 83-87.
[3].    Choi, J., et al., Antioxidant effect of astragalin isolated from the leaves of Morus alba L. against free radical-induced oxidative hemolysis of human red blood cells. Arch Pharm Res, 2013. 36(7): p. 912-7.
[4].    Kotani, M., et al., Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice. J Allergy Clin Immunol, 2000. 106(1 Pt 1): p. 159-66.