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SHMT-IN-2
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
SHMT-IN-2图片
CAS NO:2102681-49-0
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
SHMT-IN-2 (compound 2) 是一种特异性人SHMT1/2 小分子抑制剂，对 SHMT1 和 SHMT2 的 IC50值分别为 13 nM 和 66 nM。SHMT-IN-2 (compound 2) 可以抑制许多人类癌细胞的生长，对B细胞淋巴瘤有敏感性。
Cas No.2102681-49-0
分子式C22H24F3N5O
分子量431.45
溶解度DMSO : 100 mg/mL (231.78 mM; Need ultrasonic)
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SHMT-IN-2 (compound 2) is a stereo specific small-molecule inhibitor of human SHMT1/2 with IC50 values of 13 nM and 66 nM for SHMT1 and SHMT2, respectively. SHMT-IN-2 (compound 2) can block the growth of many human cancer cells, and has sensitivity for B-cell lymphomas[1].

SHMT-IN-2 (compound 2) can inhibit cell growth with cellular IC50 values of 2800 nM and 36 nM for SHMT1 and SHMT2, respectively. SHMT-IN-2 (compound 2) shows the growth sensitivity with the median IC50 was 4 μM to a panel of nearly 300 human cancer cell lines (with IC50 values of 1.72 μM and 1.73 μM for CCRF-CEM and HT,respectively), cell lines of B-cell lymphoma origin were enriched in the more sensitive half of cells[1].

[1]. regory S Ducker, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409.