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Simufilam
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Simufilam图片
CAS NO:1224591-33-6
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Simufilam 是一种低毒的,具有口服活性的 filamin A (FLNA) 激活剂。Simufilam 可优先结合改变的 FLNA,并恢复其天然构象,恢复受体和突触活性,并减少其与 a7nAChR/TLR4 的关联和下游病理作用。Simufilam 可用于阿尔茨海默症的研究。
Cas No.1224591-33-6
别名PTI-125
分子式C15H21N3O
分子量259.35
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Simufilam (PTI-125) is a low toxicity, orally active filamin A (FLNA) activator. Simufilam preferentially binds altered FLNA and restores its native conformation, restores receptor and synaptic activities, reduces its a7nAChR/TLR4 associations and downstream pathologies. Simufilam can be used for the research of Alzheimer’s disease[1].

Simufilam (1 pM~1 nM) dose-dependently improves NMDA/glycine-induced Arc expression[1].Simufilam (1 nM, 1 hour) largely restores filamin A to its native conformation and is effective in normalizing receptor activities in AD frontal cortices. Simufilam dose-dependently reduces Ab42-induced FLNA coupling to a7nAChR and TLR4 in both Ab42-treated control and AD hippocampus. Simufilam reduces Ab42’s binding affinity for a7nAChR, thereby prevents Ab42’s signaling and further accumulation on a7nAChRs[1].

Simufilam (P.o.; 2 months) restores FLNA to its native conformation. Simufilam (22 mg/kg; p.o.) robustly reduces FLNAea7nAChR/TLR4 associations. Simufilam significantly improves spatial memory. Simufilam significantly improves working memory[1].

[1]. Wang HY, et al. PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer’s disease pathogenesis. Neurobiol Aging. 2017;55:99-114.