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Chlorhexidine-d8(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Chlorhexidine-d8(hydrochloride)图片
CAS NO:2012598-75-1
包装:1mg
市场价:4037元

产品介绍
An internal standard for the quantification of chlorhexidine
Cas No.2012598-75-1
Canonical SMILESClC(C([2H])=C1[2H])=C([2H])C([2H])=C1NC(NC(NCCCCCCNC(NC(NC2=C([2H])C([2H])=C(C([2H])=C2[2H])Cl)=N)=N)=N)=N.Cl.Cl
分子式C22H22Cl2D8N10•2HCl
分子量586.4
溶解度DMSO: soluble,Methanol: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Chlorhexidine-d8is intended for use as an internal standard for the quantification of chlorhexidine by GC- or LC-MS. Chlorhexidine is abis(biguanide) antimicrobial disinfectant and antiseptic agent.1It inhibits growth of clinical methicillin-resistantS. aureus(MRSA) isolates (MIC90= 4 μg/ml).2It is also active against canine isolates of MRSA, methicillin-susceptibleS. aureus(MSSA), methicillin-resistantS. pseudintermedius(MRSP), and methicillin-susceptibleS. pseudintermedius(MSSP; MIC90s = 4, 2, 2, and 1 mg/L, respectively).3Chlorhexidine inhibits growth ofE. faeciumstrains (MICs = 1.2-19.6 μg/ml) andC. albicans(MIC = 5.15 μg/ml).4,5It generates cations that bind to and destabilize the bacterial cell wall to induce death.6Chlorhexidine also completely inhibits matrix metalloproteinase-2 (MMP-2) and MMP-9 when used at concentrations of 0.0001 and 0.002%, respectively, in a gelatin degradation assay.7Formulations containing chlorhexidine have been used in antiseptic wound dressings, mouthwash, and toothpaste.

1.Karpiński, T.M., and Szkaradkiewicz, A.K.Chlorhexidine--Pharmaco-biological activity and applicationEur. Rev. Med. Pharmacol. Sci.19(7)1321-1326(2015) 2.McDanel, J.S., Murphy, C.R., Diekema, D.J., et al.Chlorhexidine and mupirocin susceptibilities of methicillin-resistant Staphylococcus aureus from colonized nursing home residentsAntimicrob. Agents Chemother.57(1)552-558(2013) 3.Clark, S.M., Loeffler, A., and Bond, R.Susceptibility in vitro of canine methicillin-resistant and -susceptible staphylococcal isolates to fusidic acid, chlorhexidine and miconazole: Opportunities for topical therapy of canine superficial pyodermaJ. Antimicrob. Chemother.70(7)2048-2052(2015) 4.Bhardwaj, P., Hans, A., Ruikar, K., et al.Reduced chlorhexidine and daptomycin susceptibility in vancomycin-resistant enterococcus faecium after serial chlorhexidine exposureAntimicrob. Agents Chemother.62(1)e01235-01217(2017) 5.Scheibler, E., da Silva, R.M., Leite, C.E., et al.Stability and efficacy of combined nystatin and chlorhexidine against suspensions and biofilms of Candida albicansArch. Oral Biol.8970-76(2018) 6.Barrett-Bee, K., Newboult, L., and Edwards, S.The membrane destabilising action of the antibacterial agent chlorhexidineFEMS Microbiol. Lett.119(1-2)249-253(1994) 7.Gendron, R., Grenier, D., Sorsa, T., et al.Inhibition of the activities of matrix metalloproteinases 2, 8, and 9 by chlorhexidineClin. Diag. Lab. Immun.6(3)437-439(1999)