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Zileuton-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Zileuton-d4图片
CAS NO:1189878-76-9
包装与价格:
包装价格(元)
500 μg电议
1mg电议

产品介绍
An internal standard for the quantification of zileuton
Cas No.1189878-76-9
别名齐留通 d4
Canonical SMILESON(C(N)=O)C(C([2H])([2H])[2H])([2H])C1=CC2=CC=CC=C2S1
分子式C11H8D4N2O2S
分子量240.3
溶解度DMSO: slightly soluble,Methanol: very slightly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Zileuton-d4is intended for use as an internal standard for the quantification of zileuton by GC- or LC-MS. Zileuton is a reversible 5-lipoxygenase (5-LO) inhibitor.1It inhibits 5-LO activity in rat basophilic leukemia-1 (RBL-1) cell supernatant with an IC50value of 0.5 µM. Zileuton inhibits leukotriene B4production induced by the calcium ionophore A23187 in purified human peripheral blood polymorphonuclear leukocytes (PMNLs; IC50= 0.6 µM). Zileuton (10 mg/kg, p.o.) prevents antigen challenge-induced increases in specific lung resistance in a sheep model of asthma at 4 to 8 hours post-challenge following administration 2 hours pre-challenge.2Formulations containing zileuton have been used in the prophylaxis and chronic treatment of asthma.

1.Carter, G.W., Young, P.R., Albert, D.H., et al.5-Lipoxygenase inhibitory activity of zileutonJ. Pharmacol. Exp. Ther.256(3)929-937(1991) 2.Abraham, W.M., Ahmed, A., Cortes, A., et al.The 5-lipoxygenase inhibitor zileuton blocks antigen-induced late airway responses, inflammation and airway hyperresponsiveness in allergic sheepEur. J. Pharmacol.217(2-3)119-126(1992)