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Resolvin D2-d5
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Resolvin D2-d5图片
CAS NO:1881277-33-3
包装与价格：
包装价格(元)
10 μg电议
25 μg电议

产品介绍
An internal standard for the quantification of RvD2
Cas No.1881277-33-3
别名RvD2-d5
Canonical SMILES[2H]C([2H])(C([2H])([2H])[2H])/C=C\C[C@H](O)[C@H](O)/C=C/C=C/C=C\C=C\[C@@H](O)C/C=C\CCC(O)=O
分子式C22H27D5O5
分子量381.5
储存条件Store at -80℃,protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Resolvin D2-d5 (RvD2-d5) is intended for use as an internal standard for the quantification of resolvin D2 by GC- or LC-MS. Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).1In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.2Resolvin D2 is produced physiologically from the sequential oxygenation of DHA by 15-and 5-lipoxygenase and functions to dampen excessive neutrophil trafficking to sites of inflammation.3It reduces zymosan-stimulated PMN infiltration by 70% at doses as low as 10 pg per mouse and significantly reduces PAF-stimulated leukocyte adherence and emigration at 1 nM.3Also, by stimulating nitric oxide production, resolvin D2 dose dependently decreases leukocyte-endothelial interactions. In a murine model of sepsis, resolvin D2 reduces leukocyte and PMN infiltration, decreases production of pro-inflammatory cytokines, and promotes phagocyte-mediated bacterial clearance.3

1.Hong, S., Gronert, K., Devchand, P.R., et al.Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammationJ. Biol. Chem.278(17)14677-14687(2003) 2.Ariel, A., and Serhan, C.N.Resolvins and protectins in the termination program of acute inflammationTRENDS in Immunology28(4)176-183(2007) 3.Spite, M., Norling, L.V., Summers, L., et al.Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsisNature461(7268)1287-1291(2009)