TRAF-STOP inhibitor 6877002

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

433249-94-6

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议

产品介绍

TRAF-STOP inhibitor 6877002，一种抑制 CD40-TRAF6 相互作用的选择性抑制剂，从专利 WO2014033122A1 中获得，抑制 RAW 细胞中 NF-κB 活化，化合物VII。TRAF-STOP 6877002 可阻止小鼠中已发生的动脉粥样硬化恶化，减少白细胞募集并减少巨噬细胞活化；减少动脉粥样硬化斑块中的巨噬细胞增殖。

Cas No.	433249-94-6
Canonical SMILES	O=C(C1=CC=CC=C1)/C=C/NC2=C(C=CC(C)=C2)C
分子式	C₁₇H₁₇NO
分子量	251.32
溶解度	DMSO: 125 mg/mL (497.37 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1[1]. TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces macrophage proliferation in atherosclerotic plaques[2]. [1]. Seijkens TTP, et al. Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis. J Am Coll Cardiol. 2018 Feb 6;71(5):527-542.