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TRAF-STOP inhibitor 6877002
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TRAF-STOP inhibitor 6877002图片
CAS NO:433249-94-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
TRAF-STOP inhibitor 6877002,一种抑制 CD40-TRAF6 相互作用的选择性抑制剂,从专利 WO2014033122A1 中获得,抑制 RAW 细胞中 NF-κB 活化,化合物VII。TRAF-STOP 6877002 可阻止小鼠中已发生的动脉粥样硬化恶化,减少白细胞募集并减少巨噬细胞活化;减少动脉粥样硬化斑块中的巨噬细胞增殖。
Cas No.433249-94-6
Canonical SMILESO=C(C1=CC=CC=C1)/C=C/NC2=C(C=CC(C)=C2)C
分子式C17H17NO
分子量251.32
溶解度DMSO: 125 mg/mL (497.37 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1[1]. TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces macrophage proliferation in atherosclerotic plaques[2].

[1]. Seijkens TTP, et al. Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis. J Am Coll Cardiol. 2018 Feb 6;71(5):527-542.