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Minerval
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Minerval图片
CAS NO:56472-29-8
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
Minerval (2-Hydroxyoleic acid) 是一种合成油酸 (OA) 衍生物,可与质膜结合并改变脂质组织。 Minerval 具有抗肿瘤作用。
Cas No.56472-29-8
别名2-羟基乳清酸,2-Hydroxyoleic acid; 2-OHOA
Canonical SMILESCCCCCCCC/C=C\CCCCCCC(O)C(O)=O
分子式C18H34O3
分子量298.46
溶解度Soluble in DMSO
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Minerval (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. Minerval has anti-tumor effect[1].

Minerval (25-75 μM; 72 hours) impairs Jurkat cell growth in a time- and concentration-dependent manner, with an IC50 of ~40 μM[1].Minerval (25-50 μM; 72 hours) also induces a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis[1]. Cell Viability Assay[1] Cell Line: Jurkat cells

Minerval markedly and significantly inhibits tumour growth in nude mice infected with Jurkat cells[1]. Animal Model: 6-week-old nude male mice (Jurkat cells xenograft model)[1]

[1]. Llado V, et al. Minerval induces apoptosis in Jurkat and other cancer cells. J Cell Mol Med. 2010 Mar;14(3):659-70.