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(±)-trans-GK563
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(±)-trans-GK563图片
CAS NO:2351820-19-2
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A GVIA iPLA2inhibitor
Cas No.2351820-19-2
Canonical SMILESO=C1[C@@H](CCCCC2=CC=CC=C2)[C@H](CCC)O1
分子式C16H22O2
分子量246.3
溶解度Chloroform: slightly soluble,DMSO: slightly soluble,Methanol: slightly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

trans-(±)-GK563 is a potent β-lactone inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (GVIA iPLA2; IC50 = 1 nM).1 It is selective for GVIA iPLA2 over GVIA cPLA2 (IC50 = 22 μM). trans-(±)-GK563 (1 and 10 μM) inhibits apoptosis induced by IL-1β and IFN-γ in INS-1 β-cells.

|1. Dedaki, C., Kokotou, M.G., Mouchlis, V.D., et al. β-Lactones: A novel class of Ca2+-independent phospholipase A2 (group VIA iPLA2) inhibitors with the ability to inhibit β-cell apoptosis. J. Med. Chem. 62(6), 2916-2927 (2019).