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Tenovin-6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tenovin-6图片
CAS NO:1011557-82-6
规格:≥98%
包装与价格:
包装价格(元)
1mg电议
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)454.63
FormulaC25H34N4O2S
CAS No.1011557-82-6
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 98 mg/mL (215.55 mM)
Water:<1 mg/mL (slightly soluble or insoluble)
Ethanol: <1 mg/mL (slightly soluble or insoluble)
Solubility (In vivo)Tenovin-6; Tenovin 6; Tenovin6
实验参考方法
GeneralTenovin-6 is a more water-soluble analog of tenovin-1. Tenovin-6 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 of 21 μM, 10 μM, and 67 μM, respectively.
Animal modelARN8 melanoma cells were injected into the flank of SCID mice and allowed to develop into tumors.
Formulation
Dosages 50 mg/kg
Administration i.p.
References[1] Lain S, et al. Cancer Cell, 2008, 13(5), 454-463.
生物活性

Tenovin-6 Delays Tumor Growth In Vivo. Lain S, et al. Cancer Cell, 2008, 13(5), 454-463.

Tenovin-6 Inhibits the Protein Deacetylase Activities of Purified Sirtuins SirT1 and SirT2