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Pitstop2
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Pitstop2图片
CAS NO:1332879-52-3
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Pitstop2 是一种选择性网格蛋白介导的内吞作用 (CME) 抑制剂。
Cas No.1332879-52-3
化学名N-[5-[(4-bromophenyl)methylene]-4,5-dihydro-4-oxo-2-thiazolyl]-1-naphthalenesulfonamide
Canonical SMILESO=C1/C(SC(NS(C2=C(C=CC=C3)C3=CC=C2)(=O)=O)=N1)=C/C4=CC=C(Br)C=C4
分子式C20H13BrN2O3S2
分子量473.4
溶解度20mg/mL in DMSO
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
文献引用
产品描述

Pitstop2 is an inhibitor of the interaction between the clathrin terminal domain and amphiphysin (IC50 = 12 μM).1 It inhibits clathrin-mediated transferrin uptake in HeLa and U2OS cells (IC50s = 12-15 and 9.7 μM, respectively). Pitstop2 inhibits HIV-1 entry and infectivity in HeLa reporter cell lines. It also inhibits clathrin-independent endocytosis of CD44, CD98, and CD147 in HeLa cells.2

References
1. von Kleist, L., Stahlschmidt, W., Bulut, H., et al. Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition. Cell 146(3), 471-484 (2012).
2. Dutta, D., Williamson, C.D., Cole, N.B., et al. Pitstop 2 is a potent inhibitor of clathrin-independent endocytosis. PLoS One 7(9), e45799 (2012).