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Streptonigrin(Bruneomycin)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Streptonigrin(Bruneomycin)图片
CAS NO:3930-19-6
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Streptonigrin (Bruneomycin) (Bruneomycin) 是由 Streptomyces flocculus 产生的天然产物,具有抗肿瘤和抗菌活性。
Cas No.3930-19-6
别名棕霉素,Bruneomycin
Canonical SMILESO=C(C1=NC(C2=NC3=C(C(C(OC)=C(N)C3=O)=O)C=C2)=C(N)C(C4=CC=C(OC)C(OC)=C4O)=C1C)O
分子式C25H22N4O8
分子量506.46
溶解度Chloroform:Methanol (1:1): 2 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Streptonigrin (Bruneomycin), a natural product produced by Streptomyces flocculus, possesses both anti-tumor and anti-bacterial activity. Streptonigrin acts as a pan-PAD inhibitor with IC50s of 48.3±34.2 µM, 26.1±0.3 µM, 0.43±0.03 µM, and 2.5±0.4 µM for PAD1, PAD2, PAD3, and PAD4, respectively[1].

[1]. Dreyton CJ, et al. Insights into the mechanism of Streptonigrin-induced protein arginine deiminase inactivation. Bioorg Med Chem. 2014 Feb 15;22(4):1362-9.