Docosanoic acid-d₄is intended for use as an internal standard for the quantification of docosanoic acid by GC- or LC-MS. Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut andM. oleiferaseed oils.^1,2It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (K_d= 12 nM).³Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase Λ activity in cell-free enzyme assays when used at a concentration of 100 µM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 µM.⁴Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet but not a high-cholesterol diet.⁵Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.

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