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Bitertanol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bitertanol图片
CAS NO:55179-31-2
包装与价格:
包装价格(元)
25mg电议
50mg电议

产品介绍
A triazole fungicide
Cas No.55179-31-2
别名联苯三唑醇
Canonical SMILESOC(C(C)(C)C)C(N1N=CN=C1)OC(C=C2)=CC=C2C3=CC=CC=C3
分子式C20H23N3O2
分子量337.4
溶解度Chloroform: slightl soluble,DMSO: Slightly Soluble,Methanol: Slightly Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Bitertanol is a broad-spectrum triazole fungicide that is active against a variety of fungi, includingV. inaequalisandV. pirina, which are responsible for apple and pear scab, respectively, as well asS. mors-uvaeandP. ribis, which are responsible for American gooseberry mildew and leaf spot in black currants, respectively.1It is active against isolates ofV. inaequalis(MICs = 0.6 and 1 µg/ml) but repeated use leads to resistance and cross-resistance (MICs = 9.8-13 µg/ml for bitertanol-resistant isolates).2Bitertanol inhibits the cytochrome P450 (CYP450) isoform CYP3A4 (IC50= 2.74 µM) and inhibits androgenic activity induced by the androgen receptor agonist DHT in a yeast two-hybrid assay (IC50= 79.85 µM).3In rats, bitertanol (10-300 mg/kg, i.p.) increases operant responding on one- and five-minute fixed interval schedules with no effect on motor activity.4

1.Birch, P.A., Rose, P.W., and Wainwright, A.A broad spectrum fungicide of the triazole group for use in pome and bush fruitBrit. Crop Prot. Conf. - Pests and Dis., Proc.11(2)545-554(1981) 2.Hildebrand, P.D., Lockhart, C.L., Newberry, R.J., et al.Resistance of Venturia inaequalis to bitertanol and other demethylation-inhibiting fungicidesCan. J. Plant Path.10(4)311-316(1988) 3.Lv, X., Pan, L., Wang, J., et al.Effects of triazole fungicides on androgenic disruption and CYP3A4 enzyme activityEnviron. Pollut.222(2016)504-512(2017) 4.Allen, A.R., and MacPhail, R.C.Bitertanol, a triazole fungicide, increases operant responding but not motor activityNeurotoxicol. Teratol.15(4)237-242(1993)