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5-Methyltetrahydrofolic Acid(hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
5-Methyltetrahydrofolic Acid(hydrate)图片
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A biologically active form of folic acid
Canonical SMILESO=C1C2=C(NCC(CNC3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)C=C3)N2C)NC(N)=N1.O
分子式C20H25N7O6.XH2O
分子量459.5
溶解度DMF: 10 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

5-Methyltetrahydrofolic acid is a biologically active form of folic acid that functions, in conjunction with vitamin B12, as a methyl-group donor involved in the conversion of homocysteine to methionine.1,2The availability of methyl groups is essential for a variety of methylation reactions including the synthesis of DNA and proper neural tube closure.1It has been used to restore nitric oxide-generating activity in cases of familial hypercholesterolemia or hyperhomocysteinemia, reducing homocysteine levels and improving vascular endothelial function.3,4

1.Blom, H.J., and Smulders, Y.Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defectsJ.Inherit.Metab.Dis.34(1)75-81(2011) 2.5-Methyltetrahydrofolate. MonographAltern.Med.Rev.11(4)330-337(2006) 3.Verhaar, M.C., Wever, R.M.F., Kastelein, J.J.P., et al.5-Methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemiaCirculation97237-241(1998) 4.Zhang, X., Li, H., Jin, H., et al.Effects of homocysteine on endothelial nitric oxide productionAmerican Journal of Physiology.Renal Physiology279(4)671-678(2000)