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1,1'-(Azodicarbonyl)dipiperidine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
1,1'-(Azodicarbonyl)dipiperidine图片
CAS NO:10465-81-3
包装与价格：
包装价格(元)
1 g电议
5 g电议
10 g电议

产品介绍
A Mitsunobu reagent
Cas No.10465-81-3
别名偶氮二甲酰二哌啶
Canonical SMILESO=C(/N=N/C(N1CCCCC1)=O)N2CCCCC2
分子式C12H20N4O2
分子量252.3
溶解度DMF: 10 mg/ml,DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml,Ethanol: 1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

1,1'-(Azodicarbonyl)dipiperidine (ADDP) is a reagent commonly used in the Mitsunobu reaction for the condensation of an alcohol and an acidic compound.1,2It has been used as a reagent in the synthesis of G protein-coupled receptor 120 (GPR120) agonists with antidiabetic activity and peroxisome proliferator-activated receptor α (PPARα), PPARγ, and PPARδ triple agonists.3,4

1.Tsunoda, T., Yamamiya, Y., and ItÔ, S.1,1′-(Azodicarbonyl)dipiperidine-tributylphosphine, a new reagent system for Mitsunobu reactionTetrahedron Lett.34(10)1639-1642(1993) 2.Hirose, D., Gazvoda, M., Košmrlj, J., et al.Systematic evaluation of 2-arylazocarboxylates and 2-arylazocarboxamides as Mitsunobu reagentsJ. Org. Chem.83(8)4712-4729(2018) 3.Zhang, X., Cai, C., Winters, M., et al.Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonistsBioorg. Med. Chem. Lett.27(15)3272-3278(2017) 4.Mogensen, J.P., Jeppesen, L., Bury, P.S., et al.Design and synthesis of novel PPARα/γ/δ triple activators using a known PPARα/γ dual activator as structural templateBioorg. Med. Chem. Lett.13(2)257-260(2003)