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Sterigmatocystin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Sterigmatocystin图片
CAS NO:10048-13-2
包装与价格：
包装价格(元)
500μg电议
1mg电议
10mg电议

产品介绍
Sterigmatocystin 是黄曲霉毒素和霉菌毒素的前体，由杂色曲霉的常见霉菌菌株产生。
Cas No.10048-13-2
别名甾体半胱氨酸
Canonical SMILESOC1=CC=CC(O2)=C1C(C3=C2C([C@@](C=CO4)([H])[C@@]4([H])O5)=C5C=C3OC)=O
分子式C18H12O6
分子量324.3
溶解度Acetone: 5 mg/ml
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor[1][2]. Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals[3].

Sterigmatocystine-induced DNA damage activates the ATM/53-dependent signaling pathway, which contributes to the induction of G2 arrest in GES-1 cells[4].

Sterigmatocystine (ip; 3 mg/kg once daily for 14 days) inhibits p21WAF1/CIP1[3].

References:
[1]. Kusunoki M, et al. Long-term administration of the fungus toxin, sterigmatocystin, induces intestinal metaplasia and increases the proliferative activity of PCNA, p53, and MDM2 in the gastric mucosa of aged Mongolian gerbils. Environ Health Prev Med. 2011 Jul;16(4):224-31.
[2]. Schroeder HW, et al. Production of sterigmatocystin by some species of the genus Aspergillus and its toxicity to chicken embryos. Appl Microbiol. 1975 Oct;30(4):589-91.
[3]. Tong YF, et al. Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1 Facilitates the Development of CardiacHypertroph. Cell Physiol Biochem. 2017;42(4):1645-1656.
[4]. Zhang D, et al. Sterigmatocystin-induced DNA damage triggers G2 arrest via an ATM/p53-related pathway in human gastric epithelium GES-1 cells in vitro. PLoS One. 2013 May 21;8(5):e65044.