Becatecarin 是一种具有抗肿瘤作用的瑞贝卡霉素类似物。 Becatecarin 嵌入 DNA 并抑制拓扑异构酶 I/II 的催化活性。
| Cas No. | 119673-08-4 |
| 别名 | NSC 655649; BMS 181176; BMY 27557 |
| Canonical SMILES | O=C(N(CCN(CC)CC)C1=O)C2=C1C(C(C=CC=C3Cl)=C3N4[C@@H]5O[C@H](CO)[C@@H](OC)[C@H](O)[C@H]5O)=C4C6=C2C7=C(C(Cl)=CC=C7)N6 |
| 分子式 | C33H34Cl2N4O7 |
| 分子量 | 669.6 |
| 溶解度 | DMSO: Soluble,Water: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin. It intercalates into DNA, stabilizing the DNA-topoisomerase complex. This results in the potent catalytic inhibition of both topoisomerases I and II, initiating DNA cleavage and apoptosis. Becatecarin, alone or in combination with other compounds, has anti-cancer as well as myelosuppressive effects in vivo. It is also a transport substrate of the ATP-binding cassette (ABC) transporter ABCG2. |
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