Aloisine RP106 (compound 38) 是 Cdk1/cyclin B、Cdk5/p25 和 GSK3 的有效抑制剂，IC50 分别为 0.70μM、1.5μM、0.92 μM。
| Cas No. | 496864-15-4 |
| 别名 | 7-丁基-6-(4-甲氧基苯基)-5H-吡咯并[2,3-B]吡嗪 |
| 化学名 | 7-butyl-6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine |
| Canonical SMILES | COC(C=C1)=CC=C1C2=C(CCCC)C3=NC=CN=C3N2 |
| 分子式 | C17H19N3O |
| 分子量 | 281.4 |
| 溶解度 | DMF: 25 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml,DMSO: 12 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Aloisine is an inhibitor of Cdk1/cyclin B, Cdk5/p25, and GSK3 (IC50s = 0.70, 1.5, and 0.92 uM, respectively). It is a derivative of the aloisines A and B, which competitively inhibit ATP binding to the catalytic subunit of CDKs and GSKs. |
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