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Prostaglandin A2
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Prostaglandin A2图片
CAS NO:13345-50-1
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A naturally occurring prostaglandin with antiviral/antitumor activity
Cas No.13345-50-1
别名前列腺素A2,Medullin
化学名9-oxo-15S-hydroxy-prosta-5Z,10,13E-trien-1-oic acid
Canonical SMILESO=C1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)C=C1
分子式C20H30O4
分子量334.5
溶解度50mg/mL in DMSO, 100mg/mL in ethanol, 75mg/mL in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PGA2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. PGA2 has low biological potency in most bioassays, but it does show some antiviral/antitumor activity.[1] At a 25 uM concentration, PGA2 blocks the cell cycle progression of NIH 3T3 cells at the G1 and G2/M phase .[2] It has also been shown to act as a vasodilator with natriuretic properties.[3]

Reference:
[1]. Fukushima, M., Kato, T., Narumiya, S., et al. Prostaglandin A and J: Antitumor and antiviral prostaglandins. Adv. Prostaglandin Thromboxane Leukot. Res. 19, 415-418 (1989).
[2]. Hitomi, M., Shu, J., Strom, D., et al. Prostaglandin A2 blocks the activation of G1 phase cyclin-dependent kinase without altering mitogen-activated protein kinase stimulation. J. Biol. Chem. 271(16), 9376-9383 (1996).
[3]. Frolich, J.C., Sweetman, B.J., Carr, K., et al. Assessment of the levels of PGA2 in human plasma by gas chromatography-mass spectrometry. Prostaglandins 10(1), 185-195 (1975).