| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Canonical SMILES | OC1=CC=C(C[C@H](N)C(N[C@H](C)C(NCC(N(C)[C@H](C(NCCO)=O)CC2=CC=CC=C2)=O)=O)=O)C=C1.OC(C(F)(F)F)=O |
| 分子式 | C26H35N5O6.XCF3COOH |
| 分子量 | 513.6 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 5 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | DAMGO is a selective peptide agonist of the µ-opioid receptor (Kis = 1.18, 1,430, and 213 nM for human µ-, δ-, and κ-opioid receptors, respectively).1,2DAMGO displays higher efficacy than morphine for µ-opioid-induced nociception in rats.3,4 1.Hirning, L.D., Mosberg, H.I., Hurst, R., et al.Studies in vitro with ICI 174,864, [D-Pen2, D-Pen5]-enkephalin (DPDPE) and [D-Ala2, NMePhe4, Gly-ol]-enkephalin (DAGO)Neuropeptides5(4-6)383-386(1985) 2.Zhao, G.-M., Qian, X., Schiller, P.W., et al.Comparison of [Dmt1]DALDA and DAMGO in binding and G protein activation at μ, δ, and κ opioid receptorsJ. Pharmacol. Exp. Ther.307(3)947-954(2003) 3.Fang, F.G., Haws, C.M., Drasner, K., et al.Opioid peptides (DAGO-enkephalin, dynorphin A(1-13), BAM 22P) microinjected into the rat brainstem: Comparison of their antinociceptive effect and their effect on neuronal firing in the rostral ventromedial medullaBrain Res.501(1)116-128(1989) 4.Kelly, E.Efficacy and ligand bias at the μ-opioid receptorBr. J. Pharmacol.169(7)1430-1446(2013) |
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