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17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α图片
CAS NO:294856-01-2
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A prostaglandin F derivative similar to latanoprost free acid
Cas No.294856-01-2
Canonical SMILESO[C@@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](CC[C@@H](O)CCC2=CC(C(F)(F)F)=CC=C2)[C@H](O)C1
分子式C24H33O5F3
分子量458.5
溶解度DMF: 30 mg/ml,DMSO: 25 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

A number of 17-phenyl trinor prostaglandin F(17-phenyl trinor PGF) derivatives have been approved for the treatment of glaucoma.1,2,3Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.417-trifluoromethylphenyl-13,14-dihydro trinor PGFbears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl-13,14-dihydro trinor PGFwould act very much like the free acid of latanoprost.

1.Woodward, D.F., Krauss, A.H.P., Chen, J., et al.The pharmacology of Bimatoprost (LumiganTM)Survey of Ophthalmology45S337-S345(2001) 2.Stjernschantz, J.W.From PGF2α-isopropyl ester to latanoprost: A review of the development of xalatan. The proper lectureInvestigative Ophthalmology & Visual Science42(6)1134-1145(2001) 3.Sorbera, L.A., and CastaÑer, J.TravoprostDrugs Future25(1)41-45(2000) 4.Resul, B., Stjernschantz, J., No, K., et al.Phenyl-substituted prostaglandins: Potent and selective antiglaucoma agentsJournal of Medicinal Chemistry36243-248(1993)