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DS16570511
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
DS16570511图片
CAS NO:2446154-84-1
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Cas No.2446154-84-1
Canonical SMILESO=C(C1=CN(CCCC(O)=O)C2=C1C=CC=C2)C3=CC(NCC4=C(C)ON=C4C5=C(Cl)C=CC=C5Cl)=CC=C3
分子式C30H25Cl2N3O4
分子量562.4
溶解度DMSO: 30 mg/mL,DMSO: 30 mg/mL,Ethanol: 30 mg/mL,Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DS16570511 is an inhibitor of the mitochondrial calcium uniporter. It inhibits calcium uptake by mitochondria isolated from HEK293A cells, rat heart, and pig heart (IC50s = 0.86, 25, and 15 μM, respectively). DS16570511 inhibits fetal bovine serum-induced mitochondrial calcium influx as well as MCU- and MICU1-dependent increases in calcium influx in HEK293A cells (IC50 = 7 μM) but has no effect on mitochondrial membrane potential. Ex vivo, DS16570511 inhibits mitochondrial calcium overload induced by high calcium concentrations in isolated rat hearts. It also reversibly increases cardiac contractility without affecting heart rate.