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4-bromo A23187
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
4-bromo A23187图片
CAS NO:76455-48-6
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
4-Bromo A23187 是高选择性钙离子载体 A-23187 的卤代类似物。
Cas No.76455-48-6
别名4-溴代-钙离子载体,4-Bromocalcimycin
化学名6-bromo-5-(methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid
Canonical SMILESO=C(C1=C2N=C(C[C@H]3O[C@]4(O[C@H]([C@H](C)C(C5=CC=CN5)=O)[C@H](C)C[C@H]4C)CC[C@H]3C)OC2=CC(Br)=C1NC)O
分子式C29H36BrN3O6
分子量602.5
溶解度1mg/mL in DMSO, 10mg/mL in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

4-bromo A23187 is a halogenated analog of the highly selective calcium ionophore A23187. 4-bromo A23187 is non-fluorescent.[1] As a result, it is often used in experiments where fluorescent probes are employed.[2],[3]

Reference:
[1]. Deber, C.M., Tom-Kun, J., Mack, E., et al. Bromo-A23187: A nonfluorescent calcium ionophore for use with fluorescent probes. Anal.Biochem. 146(2), 349-352 (1985).
[2]. Ducreux, S., Gregory, P., and Schwaller, B. Inverse regulation of the cytosolic Ca2+ buffer parvalbumin and mitochondrial volume in muscle cells via SIRT1/PGC-1α axis. PLoS One 7(9), (2012).
[3]. Yang, J., Singh, V., Cha, B., et al. NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells. J.Biol.Chem. 288(23), 16960-16974 (2013).