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Gambogic Acid(Guttatic Acid,Guttic Acid)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Gambogic Acid(Guttatic Acid,Guttic Acid)图片
CAS NO:2752-65-0
规格:≥98%
包装与价格：
包装价格(元)
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)628.75
FormulaC38H44O8
CAS No.2752-65-0
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 100 mg/mL (159.04 mM)
Water:<1 mg/mL (slightly soluble or insoluble)
Ethanol: N/A
Synonymsss-Guttiferrin; ss-Guttiferrin; ss-Guttilactone; Cambogic acid; Guttatic acid; Guttic acid.
Other info

Chemical Name: (Z)-4-((1S,3aR,5S,11R,14aS)-8-hydroxy-2,2,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpent-3-en-1-yl)-4,7-dioxo-2,3a,4,5,7,11-hexahydro-1H-1,5-methanofuro[3,2-g]pyrano[3,2-b]xanthen-3a-yl)-2-methylbut-2-enoic acid

InChi Key: GEZHEQNLKAOMCA-RRZNCOCZSA-N

InChi Code: InChI=1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-/t23-,27+,36-,37+,38-/m1/s1

SMILES Code: O=C(O)/C(C)=C\C[C@@](C([C@]1([H])C=C23)=O)(OC(C)(C)[C@]4([H])C1)[C@@]24OC5=C(C(O)=C(C=C[C@](CC/C=C(C)/C)(C)O6)C6=C5C/C=C(C)\C)C3=O

实验参考方法
In VitroGambogic Acid is a caged xanthone that is derived from Garcinia hanburyi and functions as a strong apoptotic inducer in many types of cancer cells by inhibiting human Bcl-2 family proteins and activating caspases. Gambogic Acid also blocks Kir2.1 channels with EC50 of ≤ 100 nM. Gambogic Acid significantly inhibits human umbilical vein endothelial cell (HUVEC) proliferation, migration, invasion, tube formation, and micro-vessel growth at nM concentration.
In VivoGambogic Acid effectively inhibits tumor angiogenesis and suppressed tumor growth with low side effects using metronomic chemotherapy with Gambogic Acid. The results indicated that iv injection of GGA 2, 4, and 8 mg/kg inhibited dramatically the growth of human hepatocellular cell line SMMC-7721 in nude mice from the early administration.
Animal modelBALB/c nude mice bearing SMMC-7721 xenografts
Formulation & DosageIntravenous injection, 2, 4, and 8 mg/kg, 3 times per week
ReferencesActa Pharmacologica Sinica, 2004, 25: 769-774.
生物活性




Gambogic acid neutralizes ability of Bcl-2-family proteins to suppress tBid-induced mitochondrial leakage. Zhai D, et al. Mol Cancer Ther. 2008 Jun;7(6):1639-46.



Gambogic acid inhibits binding of FITC-BH3 peptide to anti-apoptotic Bcl-2 family proteins. Mol Cancer Ther. 2008 Jun;7(6):1639-46.



Effects of Bcl-2 over-expression or Bax/Bak DKO on Gambogic acid-induced cytotoxicity. Mol Cancer Ther. 2008 Jun;7(6):1639-46.

TR-FRET assay confirms gambogic acid competes with BH3 peptide for binding to Bcl-XL. Mol Cancer Ther. 2008 Jun;7(6):1639-46.

Gambogic acid induces apoptosis of cancer cells. Mol Cancer Ther. 2008 Jun;7(6):1639-46.

Comparison of cytotoxic activity and BH3 peptide displacement activity of Gambogic acid and analogs. Mol Cancer Ther. 2008 Jun;7(6):1639-46.