您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Boldine
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Boldine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Boldine图片
CAS NO:476-70-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
20mg电议

产品介绍
Boldine 是一种从山苍子根中提取的阿朴啡异喹啉生物碱,还具有这些特性,包括抗氧化、抗炎和细胞保护作用。
Cas No.476-70-0
别名波尔定
Canonical SMILESOC1=C(OC)C2=C3[C@](N(C)CCC3=C1)([H])CC4=CC(O)=C(OC)C=C42
分子式C19H21NO4
分子量327.4
溶解度DMF: 50 mg/mL,DMSO: 50 mg/mL,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL,Ethanol: 30 mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Boldine is an aporphine isoquinoline alkaloid extracted from the root of Litsea cubeba and also possesses these properties, including antioxidant, anti-inflammatory and cytoprotective effects. Boldine suppresses osteoclastogenesis, improves bone destruction by down-regulating the OPG/RANKL/RANK signal pathway and may be a potential therapeutic agent for rheumatoid arthritis[1].

References:
[1]. Zhao H , et al. Boldine isolated from Litsea cubeba inhibits bone resorption by suppressing the osteoclast differentiation in collagen-induced arthritis. Int Immunopharmacol. 2017 Oct;51:114-123.