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Pomalidomide(CC4047 or actimid)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pomalidomide(CC4047 or actimid)图片
CAS NO:19171-19-8
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议
1g电议
2g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)273.24
FormulaC13H11N3O4
CAS No.19171-19-8
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 55 mg/mL (201.28 mM) )
Water:<1 mg/mL (slightly soluble or insoluble)
Ethanol: <1 mg/mL
Solubility (In vivo) 1% DMSO+30% polyethylene glycol+1% Tween 80: 15 mg/mL
Chemical Name/Synonyms4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; CC4047; CC 4047; CC-4047; Brand name: Pomalyst.
实验参考方法
In VitroPomalidomide at 1 μM increased HbF production in human erythroid cells. After 6 days, Pomalidomide at 1 μM induced γ-globin mRNA levels upregulation 2-fold while decreased β-globin levels 2-fold.
In VivoPomalidomide enhances the antitumor effect of rituximab against B-cell lymphomas in severe combined immunodeficient mice.
Animal modelDisseminated lymphoma-bearing SCID mice
Formulation & DosageDissolved in DMSO to make a 10 mg/mL stock solution and diluted to a final concentration of 1 mg/mL in sterile 0.9% normal saline. 0.5 mg/kg; i.p.
References[1] Hernandez-Ilizaliturri FJ, et al. Clin Cancer Res, 2005, 11(16), 5984-5992.
生物活性