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SARS-CoV-IN-2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SARS-CoV-IN-2图片
CAS NO:888958-26-7
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
SARS-CoV-IN-2 是一种有效的 SARS-CoV 复制抑制剂。在 Vero 细胞中,SARS-CoV-IN 1 抗冠状病毒,EC50 为 1.9 μM。SARS-CoV-IN-2 抑制 P. falciparum 3D7 和 W2 株,IC50 分别为 21.5 和 30 nM;IC90 分别为 51.0 和 99.9 nM。在 MT-4 细胞中,SARS-CoV-IN-2 降低 HIV-1 诱导的细胞病变,EC50 为 2.9 μM。具有抗疟和抗病毒活性。
Cas No.888958-26-7
Canonical SMILESCN(CCO)CC12=C3[Fe+2]1456789([C-]%10C6=C7C8=C9%10)[C-]2(C4=C53)CNC%11=CC=NC%12=C%11C=CC(Cl)=C%12
分子式C24H18ClFeN3O
分子量455.72
溶解度DMSO: 19.23 mg/mL (42.20 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SARS-CoV-IN-2 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-2 shows anti-Coronavirus activity with an EC50 of 1.9 μM in Vero cells. SARS-CoV-IN-2 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 21.5 and 30 nM; and IC90s of 51.0 and 99.9 nM; respectively. SARS-CoV-IN-2 reduces HIV-1-induced cytopathic effect with an EC50 of 2.9 μM in MT-4 cells. Antimalarial and Antiviral Activities[1].

[1]. Biot C, et al. Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities. J Med Chem. 2006 May 4;49(9):2845-9.