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Nutlin-3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nutlin-3图片
CAS NO:890090-75-2
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)581.5
FormulaC30H30Cl2N4O4
CAS No.890090-75-2
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 100 mg/mL (171.9 mM)
Water:<1 mg/mL (slightly soluble or insoluble)
Ethanol: 30 mg/mL (51.59 mM)
Solubility (In vivo)O=C(N1C(C2=C(C=C(C=C2)OC)OC(C)C)=N[C@H](C3=CC=C(C=C3)Cl)[C@@H]1C4=CC=C(C=C4)Cl)N5CC(NCC5)=O.
Chemical Name/Synonyms4-[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one; Nutlin3a; Nutlin 3a; Nutlin-3a
实验参考方法
In VitroNutlin-3 treatment induces the expression of MDM2 and p21, and displays potent antiproliferative activity with IC50 of ~1.5 μM, only in cells with wild-type p53 such as HCT116, RKO and SJSA-1, but not in the mutant p53 cell lines SW480 and MDA-MB-435.
In VivoOral administration of Nutlin-3 at 200 mg/kg twice daily for 3 weeks significantly inhibits the tumor growth of SJAS-1 xenografts by 90%, comparable with the effect of doxorubicin treatment with 81% inhibition of tumor growth.
Animal modelAthymic female nude mice (Nu/Nu-nuBR) injected subcutaneously with SJSA-1 cells
Formulation & DosageFormulated in 2% Klucel, 0.5% Tween 80; 100 mg/kg; Oral BID
References[1] Vassilev LT, et al. Science, 2004, 303(5659), 844-848.
生物活性