Ryuvidine 是一种有效的 SET 结构域蛋白 8(SETD8) 抑制剂，IC50 为 0.5 μM，并在体外抑制 H4K20 的单甲基化。 Ryuvidine 还抑制 CDK4，IC50 为 6.0 μM，并且对一系列人类癌细胞具有细胞毒性。
| Cas No. | 265312-55-8 |
| 化学名 | 2-methyl-5-(p-tolylamino)benzo[d]thiazole-4,7-dione |
| Canonical SMILES | O=C(C1=C2SC(C)=N1)C(NC3=CC=C(C)C=C3)=CC2=O |
| 分子式 | C15H12N2O2S |
| 分子量 | 284.33 |
| 溶解度 | DMF: 5 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml,DMSO: 2 mg/ml,Ethanol: 0.5 mg/ml |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
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