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Nutlin-3a
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nutlin-3a图片
CAS NO:675576-98-4
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)581.49
FormulaC30H30Cl2N4O4
CAS No.675576-98-4
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 100 mg/mL (171.97 mM)
Water:<1 mg/mL (slightly soluble or insoluble)
Ethanol: N/A
Solubility (In vivo) 5% DMSO+55% PEG 300+ddH2O: 8 mg/mL
Chemical Name/Synonyms4-[(4S,5R)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one; Nutlin3a; Nutlin 3a; Nutlin-3a
实验参考方法
In VitroNutlin-3a stabilizes and activates p53, and induces p21 expression in a dose-dependent manner. Nutlin-3a effectively depletes the S-phase compartment to 0.2-2% and increases the G1- and G2/M-phase compartments. Nutlin-3a induces apoptosis in ~60% of SJSA-1 and MHM cells after 40 h, which increased further after 60 h (85% and 65%, respectively)
In VivoNutlin-3a suppresses xenograft growth in a dose-dependent fashion with the highest dose (200 mg/kg) showing a substantial tumor shrinkage. Nutlin-3 is a selective activator of the p53 pathway in vivo and highly efficacious against SJSA-1 osteosarcoma tumors
Animal modelNude mice bearing subcutaneous human cancer xenografts
Formulation & Dosage1% Klucel, 0.1% Tween 80; 100, 200 mg/kg; p.o.; b.i.d
References[1] Tovar C, et al. Proc Natl Acad Sci U S A, 2006, 103(6), 1888-1893.
生物活性