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YH239-EE
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
YH239-EE图片
CAS NO:1364488-67-4
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)504.41
FormulaC25H27Cl2N3O4
CAS No.1364488-67-4
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 100 mg/mL (198.3 mM)
Water:<1 mg/mL (slightly soluble or insoluble)
Ethanol: 18 mg/mL (35.7 mM)
Other info

Synonym: YH239-EE; YH239EE; YH239 EE; YH239 Ethylester;

Chemical Name: Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate

InChi Key: OTUBDDRFPQLPKD-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H27Cl2N3O4/c1-5-34-24(33)21-20(18-11-10-17(27)12-19(18)28-21)22(23(32)29-25(2,3)4)30(14-31)13-15-6-8-16(26)9-7-15/h6-12,14,22,28H,5,13H2,1-4H3,(H,29,32)

SMILES Code: O=C(C(N1)=C(C(N(CC2=CC=C(Cl)C=C2)C=O)C(NC(C)(C)C)=O)C3=C1C=C(Cl)C=C3)OCC

Chemical NameEthyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate
实验参考方法
In VitroYH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion).
In VivoN/A
Animal modelN/A
Formulation & DosageN/A
References[1] Huang Y, et al. ACS Chem Biol. 2014, 9(3), 802-811.
生物活性

Huang Y, et al. ACS Chem Biol. 2014, 9(3), 802-811.