K-Ras G12C-IN-3是突变型K-Ras G12C不可逆小分子抑制剂。
| Cas No. | 1629268-19-4 |
| Canonical SMILES | ClC(C=C(OC)C(C(N1CCN(C(C=C)=O)CC1)=O)=C2)=C2C3=CC(Cl)=CC=C3Cl |
| 分子式 | C21H19Cl3N2O3 |
| 分子量 | 453.75 |
| 溶解度 | DMSO: ≥ 30 mg/mL (66.12 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.IC50 value:Target: K-ras G12C inhibitorFor more information, please see the following patent.Heterocyclic compounds as covalent inhibitors of G12C mutant K-Ras protein useful for treating cancers, and preparation thereofBy Ren, Pingda; Liu, Yi; Li, Liansheng; Feng, Jun; Wu, Tao From PCT Int. Appl. (2014), WO 2014152588 A1 20140925. |
m.cnreagent.com