Glaucine (O,O-Dimethylisoboldine) 是一种从 Glaucium flavum Crantz 中分离出来的生物碱，具有镇咳、支气管扩张和抗炎特性。
| Cas No. | 475-81-0 |
| 别名 | 海罌粟鹼,O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396 |
| Canonical SMILES | COC1=C(OC)C2=C3[C@](N(C)CCC3=C1)([H])CC4=CC(OC)=C(OC)C=C42 |
| 分子式 | C21H25NO4 |
| 分子量 | 355.4 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Glaucine is an alkaloid originally isolated from G. flavum that demonstrates antitussive properties. It is structurally related to papaverine , a non-selective phosphodiesterase (PDE) inhibitor. Glaucine selectively inhibits PDE4 (Kis = 3.4 µM in human bronchus and polymorphonuclear leukocytes). It has been shown to have bronchodilation and anti-inflammatory effects, inhibiting the spontaneous and histamine-induced tone in human isolated bronchus and augmenting cyclic AMP accumulation. Glaucine also binds to the benzothiazepine site on L-type Ca2+-channels in smooth muscle, blocking calcium ion signaling. This compound has been detected as a recreational drug capable of eliciting dissociative effects. |
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