奎宁是一种从金鸡纳树皮中提取的生物碱，具有抗疟疾作用。
| Cas No. | 130-95-0 |
| 别名 | 奎宁 |
| Canonical SMILES | COC1=CC=C2C(C([C@@H](O)[C@]3([H])C[C@H]4[C@@H](C=C)C[N@@]3CC4)=CC=N2)=C1 |
| 分子式 | C20H24N2O2 |
| 分子量 | 324.4 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml |
| 储存条件 | 4°C, protect from light, stored under nitrogen |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Quinine is an alkaloid antimalarial agent that has MIC values ranging from 10 to 500 nM for 60 Thai isolates of P. falciparum. It inhibits hemozoin formation in purified trophozoites, leading to an increase in free heme, similar to the mechanism of action of chloroquine . In mice, quinine reduces P. berghei parasite load in the blood with a minimum effective dose (MED) of 150 mg/kg. Formulations containing quinine have been used in the treatment of uncomplicated malaria. |
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