| Cas No. | 1010096-65-7 |
| 别名 | 5-([1,1'-联苯]-4-基甲基)-N,N-二甲基-2H-四唑-2-甲酰胺 |
| Canonical SMILES | O=C(N(C)C)N1N=NC(CC(C=C2)=CC=C2C3=CC=CC=C3)=N1 |
| 分子式 | C17H17N5O |
| 分子量 | 307.4 |
| 溶解度 | DMF: 3 mg/ml,DMSO: 2 mg/ml,Ethanol: 10 mg/ml,Ethanol:PBS(pH 7.2) (1:5): 0.1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | LY2183240 is a potent, competitive small molecule inhibitor of anandamide uptake (IC50 = 270 pM; Ki = 540 pM) and hydrolysis. It has been shown to increase anandamide levels in rat cerebellum (ED50 = 1.37 mg/kg) and displays dose-dependent efficacy (3-30 mg/kg) in several rodent models of persistent pain. LY2183240 2'-isomer is a less potent, 2,5-regioisomer of LY2183240 that inhibits anandamide hydrolysis and uptake with IC50 values of 33 and 998 nM, respectively. |
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