| CAS NO: | 405060-95-9 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 2mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| Molecular Weight (MW) | 479.81 |
|---|---|
| Formula | C21H17Cl3N4OS |
| CAS No. | 405060-95-9 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 96 mg/mL (200.07 mM) |
| Water: <1 mg/mL (slightly soluble or insoluble) | |
| Ethanol: 2 mg/mL (4.16 mM) | |
| Other info | InChi Key: LCOIAYJMPKXARU-VAWYXSNFSA-N InChi Code: InChI=1S/C21H17Cl3N4OS/c22-21(23,24)19(27-17(29)12-11-14-6-2-1-3-7-14)28-20(30)26-16-10-4-8-15-9-5-13-25-18(15)16/h1-13,19H,(H,27,29)(H2,26,28,30)/b12-11+ SMILES Code: O=C(NC(NC(NC1=C2N=CC=CC2=CC=C1)=S)C(Cl)(Cl)Cl)/C=C/C3=CC=CC=C3 |
| Chemical Name | (E)-3-phenyl-N-[2,2,2-trichloro-1-(quinolin-8-ylcarbamothioylamino)ethyl]prop-2-enamide |
| In Vitro | Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Salubrinal inhibited ER stress-mediated apoptosis induced by the protein glycosylation inhibitor tunicamycin (Tm) in a dose-dependent manner, with a median effective concentration (EC50) ~ 15 μM. Salubrinal also suppressed Tm-induced DNA fragmentation the processing of caspase-7, a caspase activated by ER stress. |
|---|---|
| In Vivo | Salubrinal inhibits HSV replication in a mouse cornea infection model. Compared to vehicle control, topical Salubrinal treatment significantly reduced the viral titer recovered from eye swabs of infected animals. I.C.V. administration of Salubrinal significantly modified the homeostatic sleep response. |
| Animal model | Eight-week-old male CD-1 outbred mice |
| Formulation & Dosage | DMEM; 75μM; On cornea |
| References | [1] Boyce M, et al. Science, 2005, 307(5711), 935-939. |
 Am J Physiol Regul Integr Comp Physiol, 2009, 296(1), 178-184. |
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