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Salubrinal
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Salubrinal图片
CAS NO:405060-95-9
规格:≥98%
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)479.81
FormulaC21H17Cl3N4OS
CAS No.405060-95-9
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 96 mg/mL (200.07 mM)
Water: <1 mg/mL (slightly soluble or insoluble)
Ethanol: 2 mg/mL (4.16 mM)
Other info

InChi Key: LCOIAYJMPKXARU-VAWYXSNFSA-N

InChi Code: InChI=1S/C21H17Cl3N4OS/c22-21(23,24)19(27-17(29)12-11-14-6-2-1-3-7-14)28-20(30)26-16-10-4-8-15-9-5-13-25-18(15)16/h1-13,19H,(H,27,29)(H2,26,28,30)/b12-11+

SMILES Code: O=C(NC(NC(NC1=C2N=CC=CC2=CC=C1)=S)C(Cl)(Cl)Cl)/C=C/C3=CC=CC=C3

Chemical Name(E)-3-phenyl-N-[2,2,2-trichloro-1-(quinolin-8-ylcarbamothioylamino)ethyl]prop-2-enamide
实验参考方法
In VitroSalubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Salubrinal inhibited ER stress-mediated apoptosis induced by the protein glycosylation inhibitor tunicamycin (Tm) in a dose-dependent manner, with a median effective concentration (EC50) ~ 15 μM. Salubrinal also suppressed Tm-induced DNA fragmentation the processing of caspase-7, a caspase activated by ER stress.
In VivoSalubrinal inhibits HSV replication in a mouse cornea infection model. Compared to vehicle control, topical Salubrinal treatment significantly reduced the viral titer recovered from eye swabs of infected animals. I.C.V. administration of Salubrinal significantly modified the homeostatic sleep response.
Animal modelEight-week-old male CD-1 outbred mice
Formulation & DosageDMEM; 75μM; On cornea
References[1] Boyce M, et al. Science, 2005, 307(5711), 935-939.
生物活性

Am J Physiol Regul Integr Comp Physiol, 2009, 296(1), 178-184.