| CAS NO: | 223749-46-0 |
| 包装: | 5mg |
| 市场价: | 1350元 |
| Cas No. | 223749-46-0 |
| Canonical SMILES | CS(N([C@H]1C2=CC(OCCCC(F)(F)F)=CC=C2OC(C)(C)[C@@H]1O)C)(=O)=O |
| 分子式 | C17H24F3NO5S |
| 分子量 | 411.44 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | HMR 1556, a chromanol derivative, is a IKs blocker with IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively[1][2]. IC50: 10.5 nM (IKs in canine left ventricular myocytes), 34 nM (IKs in guinea pig left ventricular myocytes)[1] HMR 1556 inhibits Ito, ICa,L and IKr with IC50s of 33.9 μM, 27.5 μM, 12.6 μM in canine left ventricular myocytes, respectively[1]. [1]. Thomas GP, et al. HMR 1556, a potent and selective blocker of slowly activating delayed rectifier potassium current. J Cardiovasc Pharmacol. 2003 Jan;41(1):140-7. [2]. Gerlach U,et al. Synthesis and activity of novel and selective I(Ks)-channel blockers. J Med Chem. 2001 Nov 8;44(23):3831-7. |
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