Tetrabenazine D6 是氘标记的 Tetrabenazine，它是一种 VMAT 抑制剂，用于治疗多动性运动障碍。
| Cas No. | 1392826-25-3 |
| 别名 | (+)-丁苯那嗪 D6；(+)-丁苯喹嗪 D6；(+)-特苯那嗪 D6；(+)-四苯喹嗪 D6 |
| Canonical SMILES | O=C1[C@H](CC(C)C)CN2[C@](C(C=C(OC([2H])([2H])[2H])C(OC([2H])([2H])[2H])=C3)=C3CC2)([H])C1 |
| 分子式 | C19H21D6NO3 |
| 分子量 | 323.5 |
| 溶解度 | DMF: 30 mg/ml,DMF:PBS(pH7.2) (1:2): 0.33 mg/ml,DMSO: 25 mg/ml,Ethanol: 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Tetrabenazine-d6 is intended for use as an internal standard for the quantification of tetrabenazine by GC- or LC-MS. Tetrabenazine is an inhibitor of vesicular monoamine transporter 2 (VMAT2) that is selective over VMAT1 (Kis = 97 and >20,000 nM, respectively, in a serotonin uptake assay). It dose-dependently reduces levels of the monoamines norepinephrine , dopamine , and serotonin in rat brain and has been used to induce depressive-like behavior in animal models. Tetrabenazine (5 mg/kg) improves performance in balance beam and rotarod tests and prevents decreases in the number of striatal medium spiny neurons (MSNs) in a YAC128 transgenic mouse model of Huntington's disease. Formulations containing tetrabenazine have been used in the treatment of chorea associated with Huntington's disease. |
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