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Almokalant(H 234/09)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Almokalant(H 234/09)图片
CAS NO:123955-10-2
包装与价格：
包装价格(元)
250mg电议
500mg电议

产品介绍
Almokalant (H 234/09) 是一种 III 类抗心律失常药物，作为钾通道阻滞剂，可抑制时间依赖性延迟整流器 K+ 电流的特定成分 (Ikr)。
Cas No.123955-10-2
别名阿莫兰特,H 234?/09
Canonical SMILESCCCS(CCCN(CC)CC(O)COC1=CC=C(C#N)C=C1)=O
分子式C18H28N2O3S
分子量352.49
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Almokalant is a class III antiarrhythmic drug, acts as a potassium channel blocker, and inhibits a specific component (Ikr) of the time-dependent delayed rectifier K+ current.

Almokalant is a class III antiarrhythmic drug, acts as a potassium channel blocker, and inhibits a specific component (Ikr) of the time-dependent delayed rectifier K+ current[1].

Almokalant (125 μmol/kg, p.o.) induces cardiovascular defects, orofacial clefts, and tail defects in pregnant rats, after administration on Day 11. Almokalant also causes in pregnant rats[1].

[1]. Wellfelt K, et al. Teratogenicity of the class III antiarrhythmic drug almokalant. Role of hypoxia and reactive oxygen species. Reprod Toxicol. 1999 Mar-Apr;13(2):93-101.